Background: Primary adenoid cystic carcinoma (ACC) is the second most common primary tracheal neoplasms but the data for optimal treatment plan is limited. This study is an update of our institutional experience treating primary ACC of the trachea with neutron radiotherapy.
Methods: Between 1993 and 2012, 33 patients with tracheal adenoid cystic carcinoma were treated with curative intent. Two patients received surgery alone, thirteen received adjuvant neutron radiotherapy post surgical resection, and eighteen received neutron radiotherapy as a primary treatment. Median external beam neutron dose was 19.2 Gy.
Two patients who were treated with adjuvant neutron radiotherapy post surgical resection and nine patients treated with neutron radiotherapy alone were also treated with endobronchial brachytherapy boost using high-dose-rate 192Ir source (3.5Gy×2 fractions).
Median duration of follow up was 72.4 months (range 0.9–145.9 months) post treatment.
Results: Patients who underwent surgery alone, those who received adjuvant neutron radiotherapy post surgical resection, and patients who received neutron radiotherapy as a primary treatment had five-year overall survival rates of 50%, 49% and 93% (p=0.399), and five-year disease-free survival rates of 50%, 58% and 38% (p=0.702) respectively.
The five-year overall survival rates and disease free survival rates for patients who received adjuvant high-dose-rate endobronchial brachytherapy in addition to primary treatment as compared to those who did not were 89% and 72% (p=0.489) versus 46% vs 44% (p=0.251) respectively.
Conclusions: The data supports the conclusion that adenoid cystic carcinoma of the trachea can be treated with neutron radiation with favorable outcomes.
Keywords:
Published on: May 22, 2020 Pages: 15-22
Full Text PDF
Full Text HTML
DOI: 10.17352/2581-5407.000030
CrossMark
Publons
Harvard Library HOLLIS
Search IT
Semantic Scholar
Get Citation
Base Search
Scilit
OAI-PMH
ResearchGate
Academic Microsoft
GrowKudos
Universite de Paris
UW Libraries
SJSU King Library
SJSU King Library
NUS Library
McGill
DET KGL BIBLiOTEK
JCU Discovery
Universidad De Lima
WorldCat
VU on WorldCat
PTZ: We're glad you're here. Please click "create a new query" if you are a new visitor to our website and need further information from us.
If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click "take me to my Query."